Thymol-Functionalized Silica Nanomaterials Prepared by Post-Grafting Method: Preparation, Characterization, Bactericidal Activity and Mechanism Research

In this study, thymol was covalently connected to mesoporous silica nanomaterial by a post-grafting method obtain stable antibacterial system, thus overcoming the volatilization of thymol, prolonging effective time action, and enhancing efficiency thymol. It proposed for first that such synthetic route be adopted synthesize silica-based mesoporous/essential oil materials. The could capable retaining original structure, which effectively avoid porosity reduction disordered products caused condensation. Among them, minimum bactericidal concentration (MBC) functionalized MCM-41 (silica support) E. coli S. aureus were 0.3 mg mL−1 0.4 mL−1, equivalent 3/4 4/5 free (0.4 0.5 mL−1), respectively. Meanwhile, MBC SBA-15 both 0.2 also reduced These results revealed thymol-functionalized efficiently improve activities organic component. Finally, inhibition mechanism strategy discussed, referred how material directly acts on cell membrane, resulting in inactivation.